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Number of results: 65
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Abstract

From the regulatory point of view a strong link between an animal model and human pharmacodynamics of biological drugs is very important to qualify the model as “relevant”. Consistent changes in cell population between human physiology and animal model gain value of this model which then can be pharmacodynamically “relevant” from the regulatory point of view. Consequently, the aim of this study was to determine how similar to human observations is the effect of selected biological drugs on blood cells in a pig model. The study was to carry out a comparative analysis of the variability of selected biochemical and hematological parameters of the blood after administration of five different human therapeutic monoclonal antibodies (mAbs) after a single subcutaneous (SC) dose in breeding pigs. The tested drugs were siltuximab (Syl- vant®), omalizumab (Xolair®), infliximab (Inflectra®), pembrolizumab (Keytruda®), and vedoli- zumab (Entyvio®) given in a single 1 mg/kg SC injection. Each of the tested drugs exerted a sig- nificant effect on at least two of the tested parameters three weeks after the administration. Siltuximab significantly influenced 9 of the analyzed parameters. Vedolizumab significantly influenced 8 of the analyzed parameters. Infliximab had the lowest impact of all the tested drugs, as it significantly influenced only two of the analyzed parameters. The study has proved that the impact of mAbs on the analyzed parameters can be significantly extended over time. This requires the monitoring of hematological parameters in the pig model even many weeks af- ter administration of a drug in a relatively small dose.

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Authors and Affiliations

T. Grabowski
A. Burmańczuk
A. Miazek
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Abstract

To find out what affected sea level fluctuations in the past, researchers have to turn to the mountains. In ancient geological epochs, today’s Alps and Tatras were actually once on the ocean floor.

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Authors and Affiliations

Jakub Ostałowski
Jacek Grabowski
Jolanta Iwańczuk
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Abstract

In many research studies it is argued that it is possible to extract useful information about future real economic activity from the performance of financial markets. However, this study goes further and shows that it is not only possible to use expectations derived from financial markets to forecast future economic activity, but that data about the financial system can be used for this purpose as well. This paper sheds light on the ability to forecast real economic activity, based on additional and different financial variables than what have been presented so far.

The research is conducted for the Polish emerging economy on the basis of monthly data. The results suggest that, based purely on the data from the financial system, it is possible to construct reasonable measures that can, even for an emerging economy, effectively forecast future real economic activity. The outcomes are proved by two different econometric methods, namely, by a time series analysis and by a probit model. All presented models are tested in-sample and out-of-sample.

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Authors and Affiliations

Szymon Grabowski
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Abstract

This paper deals with the problem of nonstationarity of regressors in binary choice model. The limit distribution of the ML-estimator is mixed normal, but restriction testing shall not be based on standard t-statistic. The results of the conducted Monte Carlo experiment demonstrate that the true size of the restriction test is far from the significance level. Therefore, the t-Student statistic should be modified and this paper proposes its modification. The results of the Monte Carlo investigation point to the superiority of the new statistic.

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Authors and Affiliations

Wojciech Grabowski
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Abstract

This article deals with the presentation of St. Hyacinth (before 1200-1257) placed on the back seats of the stalls of the monastery churches in Poznań and Klimontów. The first known presentations of St. Hyacinth can be dated back to the fifteenth century, but certainly the canonisation of this Dominican friar (1594) gave a new impulse to creating artistic presentations and cycles. An important role in making his name more popular among Catholics was played by the graphics, which produced examples to be followed in other forms. Among the first graphics was the engraving of Raffaelo Guidi, made in 1594-1595 in Rome according to the drawing of Antonio Tempesta. One can presume that the copy of a late gothic painting from the Dominican church in Cracow served as an inspiration to produce the main scene of this print. A less elaborate engraving, taking into consideration the number of scenes depicted, was the one of Camillo Graffico, produced in Rome at this same time. In 1600 Jan Sadeler followed the concept of Guidi when he published his print in Venice. In 1601 Giacomo Lauro published in Rome a print presenting 12 scenes on the edge. This artefact inspired the Cologne publisher Peter Overadt, who printed in 1605 his engraving together with others, known as the cycle Icones et Miracula Sanctorum Poloniae. He significantly influenced Polish art in the seventeenth century. The low relief placed on the back-seats of the Poznań stalls, dating back to ca. 1620-1630, used the print of Overadt as a source for seven episodes (out of fourteen preserved). The back-seats at the church in Klimontów, produced ca. 1620-1640, include 10 scenes (out of 11) based on Overadt’s graphics. Both of these cycles were based on these same sources and were made separately, using other motifs, not always fully discovered, and indirectly some literary works were dedicated to St. Hyacinth.

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Authors and Affiliations

Paweł Grabowski
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Abstract

The objective of the research was to investigate the efficiency of selected methods of data fusion from visual sensors used on-board satellites for attitude measurements. Data from a sun sensor, an earth sensor, and a star tracker were fused, and selected methods were applied to calculate satellite attitude. First, a direct numerical solution, a numerical and analytical solution of the Wahba problem, and the TRIAD method for attitude calculation were compared used for integrating data produced by a sun sensor and an earth sensor. Next, attitude data from the star tracker and earth/sun sensors were integrated using two methods: weighted average and Kalman filter. All algorithms were coded in the MATLAB environment and tested using simulation models of visual sensors. The results of simulations may be used as an indication for the best data fusion in real satellite systems. The algorithms developed may be extended to incorporate other attitude sensors like inertial and/or GNSS to form a complete satellite attitude system.
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Authors and Affiliations

Janusz Narkiewicz
Mateusz Sochacki
Adam Rodacki
Damian Grabowski
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Abstract

The present studies explore how activating concepts pertaining to the origins of interindividual differences affect the processing of stereotypical and counterstereotypical information. The concepts, i.e., nature and nurture, are both assumed to evoke similar stereotypical expectations although nurture implies greater flexibility. The studies show that stereotypical information enhances whereas counterstereotypical information diminishes stereotyping when nurture is activated. In contrast, counterstereotypical evidence challenges what activated nature would suggest and perceivers primed with nature evince stronger stereotyping when they encounter counterstereotypical information. The results also show that priming nature leads perceivers to attribute stereotype conformity to internal causes whereas nurture accredits conformity to situational constraints. Stereotype flexibility is associated with the subjective ease with which perceivers can both imagine counterstereotypical and mentally undo stereotypical evidence.
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Authors and Affiliations

Philip Broemer
Adam Grabowski
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Abstract

Investigations have been undertaken to determine which fungi species are responsible for occurrence of sooty blotch disease in Poland. It was found that disease complex is caused by Tripospermum myrti (Lind) Hughes, Phialophora sessilis de Hoog and Peltaster fructicola Jonhson. There was no evidence of the presence fun- gus described as Gloedes pomigena which was previosly considered as a casual agent of apple sooty blotch disease in Poland.

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Authors and Affiliations

Beata Wrona
Marek Grabowski
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Abstract

The fungi that cause sooty blotch grow only on the apple skin, so they use appropriate nutrients which are present on the fruit surface. It has been shown that when the first symptoms of sooty blotch occur a noticeable increase of glucose and fructose content both on the apple skin and in juice is observed. Such increase occurs at pH 4.4. An effect of surface glucose and fructose on the growth of patho- gens responsible for the disease was also confirmed by evaluating the germination of conidia of Phialophora sessilis de Hoog and Peltaster fructicola Jonhson in solution of above mentioned sugars, distilled water and standard d-glucose solutions.

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Authors and Affiliations

Beata Wrona
Marek Grabowski
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Abstract

Magazyny energii jako elastyczny zasób wszechstronnie wspierający pracę sieci będą niezbędne, gdy zabraknie pełniących dotąd funkcje regulacyjne elektrowni cieplnych.
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Authors and Affiliations

Krzysztof Rafał
Paweł Grabowski
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Abstract

Żeby dowiedzieć się, co w przeszłości wpływało na wahania poziomu mórz, trzeba pojechać w góry – Alpy albo Tatry. One bowiem w dawnych epokach geologicznych były dnem oceanu.

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Authors and Affiliations

Andrzej Grabowski
Jolanta Iwańczuk
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Abstract

The aim of the herein paper is to present the processes of managing science and technology

parks by means of indicating their essence, types and domains of activities. Moreover, the

attributes of these parks were emphasized in the context of the innovative processes. Pilot

research was conducted which concentrated on the institutionalization and functionality of

the science and technology parks which facilitated the formulation of conclusions relating

to the cooperation between enterprises, science and technology parks and the sphere of

science in terms of innovativeness.

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Authors and Affiliations

Beata Skowron-Grabowska
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Abstract

The aim of this study was to determine to what extent the ions present in hard water (125 mg/L of MgCl2 and 500 mg/L of CaCl2) may intensify the feed-induced decrease in oxytetracycline (OTC) absorption rate in broiler chickens after single oral administration at a dose of 15 mg/kg. Drug concentrations in plasma were determined by liquid chromatography-tandem mass spectrometry and combined, compartmental and non-compartmental approach was used to assess OTC pharmacokinetics.

The administration of feed decreased the absolute bioavailability (F) of OTC from 12.70%±4.01 to 6.40%±1.08, and this effect was more pronounced after the combined administration of OTC with feed and hard water (5.31%±0.90). A decrease in the area under the concentration- time curve (AUC0-t), (from 10.18±3.24 μg·h/ml in control to 5.13 μg·h/ml±1.26 for feed and 4.26 μg·h/ml±1.10 for feed and hard water) and the maximum plasma concentration of OTC (Cmax) (from 1.22±0.18 μg/ml in control, to 1.01 μg/ml ±0.10 for hard water, 0.68 μg/ml±0.10 for feed and 0.61 μg/ml±0.10 for feed and hard water) was observed. The results of this study indicate that feed strongly decreases F, AUC0-t and Cmax of orally administered OTC. The ions present in hard water increase this inhibitory effect, which suggests that, therapy with OTC may require taking into account local water quality and dose modification, particularly when dealing with outbreaks caused by less sensitive microorganisms.

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Authors and Affiliations

H. Ziółkowski
H. Madej-Śmiechowska
T. Grabowski
J.J. Jaroszewski
T. Maślanka

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